来自马甲子的环肽生物碱。

Cyclopeptide alkaloids from Paliurus ramossisimus.

作者信息

Lin H Y, Chen C H, You B J, Liu K C, Lee S S

机构信息

School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan, Republic of China.

出版信息

J Nat Prod. 2000 Oct;63(10):1338-43. doi: 10.1021/np000136a.

DOI:10.1021/np000136a

PMID:11076548

Abstract

Seven zizyphine A-type cyclopeptide alkaloids were isolated from the roots of Paliurus ramossisimus by the combination of centrifugal partition chromatography and conventional separation methods. The novel structures of paliurines A-F (1-6) were characterized and established on the basis of MS and elaborate NMR spectral analyses. Terminal dipeptide stereochemistry was confirmed by correlation with the synthetic dipeptides via comparison of their (13)C NMR data.

摘要

通过离心分配色谱法与传统分离方法相结合，从马甲子根中分离出7种A型环肽类生物碱。基于质谱和精细的核磁共振光谱分析，对马甲子碱A - F（1 - 6）的新结构进行了表征和确定。通过比较它们的碳-13核磁共振数据，将末端二肽的立体化学与合成二肽相关联，从而得以确认。