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来自……根皮的具有罕见末端单元的新型生物活性环肽生物碱。 （原文句子不完整，缺少具体植物名称）

New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of .

作者信息

Lomchoey Natthakaln, Panseeta Panomwan, Boonsri Pornthip, Apiratikul Nuttapon, Prabpai Samran, Kongsaeree Palangpon, Suksamrarn Sunit

机构信息

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University Bangkok 10110 Thailand

Department of Chemistry, Chulachomklao Royal Military Academy Nakornnayok 26001 Thailand.

出版信息

RSC Adv. 2018 May 17;8(33):18204-18215. doi: 10.1039/c7ra13050c.

DOI:10.1039/c7ra13050c
PMID:35541146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9080573/
Abstract

Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite , with an IC value of 6.09 μM.

摘要

从粉叶小檗的根皮提取物中分离出6个新的14元环环肽生物碱，即柬埔寨小檗碱A - F（1 - 6），以及2个已知化合物，即异欧前胡内酯（7）和洛图萨宁B（8）。基于一维和二维核磁共振、高分辨质谱、电子圆二色谱和X射线晶体学数据确定了它们的结构和构型。化合物1和3是罕见的5(14)-型环肽生物碱，其末端单元含有咪唑烷-4-酮环。测试了这些环肽对三种癌细胞系的抗疟、抗结核和细胞毒性作用。化合物3对疟原虫显示出显著的抗疟活性，IC值为6.09 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/920d0eca8347/c7ra13050c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/e8cd346c438f/c7ra13050c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/188a9820e4f0/c7ra13050c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/d97ff07bf445/c7ra13050c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/800f0a5629b8/c7ra13050c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/542a08f9d00d/c7ra13050c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/920d0eca8347/c7ra13050c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/e8cd346c438f/c7ra13050c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/188a9820e4f0/c7ra13050c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/d97ff07bf445/c7ra13050c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/800f0a5629b8/c7ra13050c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/542a08f9d00d/c7ra13050c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51ce/9080573/920d0eca8347/c7ra13050c-f6.jpg

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3
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Spectrochim Acta A Mol Biomol Spectrosc. 2016 Feb 15;155:95-102. doi: 10.1016/j.saa.2015.11.002. Epub 2015 Nov 4.
4
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J Ethnobiol Ethnomed. 2015 Apr 9;11:27. doi: 10.1186/s13002-015-0011-9.
5
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Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt C:1401-8. doi: 10.1016/j.saa.2014.10.028. Epub 2014 Oct 18.
6
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7
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