May J, Lell B, Luty A J, Meyer C G, Kremsner P G
Sekton Humanparasitologie, Institut für Tropenmedizin der Universität Tübingen, Germany.
J Infect Dis. 2001 Jan 1;183(1):168-72. doi: 10.1086/317642. Epub 2000 Nov 10.
Protective immunity against Plasmodium falciparum requires constant exposure to the pathogen. T cell-mediated immune responses are induced by T cell epitopes of pre-erythrocytic stage antigens of P. falciparum and involve HLA-restricted CD4 and CD8 cells. Cytotoxic T cell responses to a conserved epitope of P. falciparum liver stage antigen (LSA) type 1 are restricted by the HLA class I allele Bw53. The role of HLA class II alleles in mediating cellular responses against P. falciparum LSA-1 has not yet been demonstrated. In a longitudinal study performed for >4 years, associations were found between the HLA class II allele DQB10501 and protection from malaria anemia and malarial reinfections in Gabonese children. Children carrying DQB10501 had a higher frequency of interferon-gamma responses to LSA-1 T cell epitopes, compared with noncarriers.
针对恶性疟原虫的保护性免疫需要持续接触该病原体。T细胞介导的免疫反应由恶性疟原虫前红细胞期抗原的T细胞表位诱导，涉及HLA限制性CD4和CD8细胞。细胞毒性T细胞对恶性疟原虫肝期抗原1（LSA-1）保守表位的反应受HLA I类等位基因Bw53限制。HLA II类等位基因在介导针对恶性疟原虫LSA-1的细胞反应中的作用尚未得到证实。在一项进行了4年多的纵向研究中，发现HLA II类等位基因DQB10501与加蓬儿童预防疟疾贫血和疟疾再感染之间存在关联。与非携带者相比，携带DQB10501的儿童对LSA-1 T细胞表位产生干扰素-γ反应的频率更高。
