Shay D K, Holman R C, Roosevelt G E, Clarke M J, Anderson L J
Respiratory and Enteric Viruses Branch and National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Infect Dis. 2001 Jan 1;183(1):16-22. doi: 10.1086/317655. Epub 2000 Nov 10.
A 1985 estimate that 4500 respiratory syncytial virus (RSV)-associated deaths occur annually among US children has not been updated using nationally representative data. Thus, 1979-1997 multiple cause-of-death records for children <5 years old listing bronchiolitis, pneumonia, or any respiratory tract disease were examined. Deaths among children associated with any respiratory disease declined from 4631 in 1979 to 2502 in 1997. During the 19-year study period, 1806 bronchiolitis-associated deaths occurred (annual mean, 95 deaths; range, 66-127 deaths). Of these deaths, 1435 (79%) occurred among infants <1 year old. Congenital heart disease, lung disease, or prematurity was listed in death records of 179 (9.9%), 99 (5.5%), and 76 (4.2%) children dying with bronchiolitis, respectively. By applying published proportions of children hospitalized for bronchiolitis or pneumonia who were RSV-infected to bronchiolitis and pneumonia deaths, it was estimated that < or =510 RSV-associated deaths occurred annually during the study period, fewer than previously estimated.
1985年一项估计称，美国每年有4500例与呼吸道合胞病毒（RSV）相关的儿童死亡病例，但尚未根据具有全国代表性的数据进行更新。因此，对1979 - 1997年5岁以下儿童的多死因记录进行了检查，这些记录列出了细支气管炎、肺炎或任何呼吸道疾病。与任何呼吸道疾病相关的儿童死亡人数从1979年的4631例下降到1997年的2502例。在19年的研究期间，发生了1806例与细支气管炎相关的死亡（年平均95例；范围为66 - 127例）。在这些死亡病例中，1435例（79%）发生在1岁以下婴儿中。在因细支气管炎死亡的儿童死亡记录中，分别有179例（9.9%）、99例（5.5%）和76例（4.2%）列出了先天性心脏病、肺部疾病或早产情况。通过将已发表的因细支气管炎或肺炎住院且感染RSV的儿童比例应用于细支气管炎和肺炎死亡病例，估计在研究期间每年发生的与RSV相关的死亡病例≤510例，少于先前的估计。
