Pekkanen J, Brunner E J, Anderson H R, Tiittanen P, Atkinson R W
Unit of Environmental Epidemiology, National Public Health Institute, PO Box 95, FIN-70701 Kuopio, Finland.
Occup Environ Med. 2000 Dec;57(12):818-22. doi: 10.1136/oem.57.12.818.
The reason for the association between air pollution and risk of cardiovascular diseases is unknown. The hypothesis was examined that daily concentrations of air pollution are associated with daily concentrations of fibrinogen, a risk factor for cardiovascular disease.
Data on concentrations of plasma fibrinogen for 4982 male and 2223 female office workers, collected in a cross sectional survey in London between September 1991 and May 1993, were combined with data on concentrations of air pollution during the day of blood sampling and during the 3 preceding days.
After adjustment for weather and other confounding factors, an increase in the 24 hour mean NO(2) during the previous day from the 10th to the 90th percentile (61.7 microg/m(3)) was associated with a 1.5% (95% confidence interval (95% CI) 0.4% to 2.5%) higher fibrinogen concentration. The respective increase for CO (1.6 mg/m(3)) was 1.5% (95% CI 0.5%, 2.5%). These associations tended to be stronger in the warm season (April to September). Significant associations were found for black smoke and particulate matter of diameter 10 microm (PM(10)) only in the warm season. No association with fibrinogen was found for SO(2) or ozone.
The short term association between air pollution, possibly from traffic, and risk of cardiovascular events may be at least partly mediated through increased concentrations of plasma fibrinogen, possibly due to an inflammatory reaction caused by air pollution.
空气污染与心血管疾病风险之间存在关联的原因尚不清楚。本研究检验了以下假设：空气污染的日浓度与纤维蛋白原（一种心血管疾病风险因素）的日浓度相关。
将1991年9月至1993年5月在伦敦进行的一项横断面调查中收集的4982名男性和2223名女性上班族的血浆纤维蛋白原浓度数据，与采血当天及前3天的空气污染浓度数据相结合。
在对天气和其他混杂因素进行调整后，前一天24小时平均二氧化氮（NO₂）浓度从第10百分位数升至第90百分位数（61.7微克/立方米），与纤维蛋白原浓度升高1.5%（95%置信区间（95%CI）0.4%至2.5%）相关。一氧化碳（CO）浓度升高1.6毫克/立方米时，纤维蛋白原浓度相应升高1.5%（95%CI 0.5%，2.5%）。这些关联在温暖季节（4月至9月）往往更强。仅在温暖季节发现黑烟和直径10微米颗粒物（PM₁₀）与纤维蛋白原存在显著关联。未发现二氧化硫或臭氧与纤维蛋白原有关联。
空气污染（可能源自交通）与心血管事件风险之间的短期关联可能至少部分是通过血浆纤维蛋白原浓度升高介导的，这可能是由于空气污染引发的炎症反应所致。
