Gwon Jun Gyo, Lee Sang Ah, Park Kye-Yeung, Oh Se Uk, Kim Joung Soo, Seo Hyun-Min
Division of Vascular Surgery, Department of Surgery, Ulsan University College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Department of Family Medicine, Hanyang University College of Medicine, Seoul 04763, Korea.
J Clin Med. 2022 Jun 19;11(12):3517. doi: 10.3390/jcm11123517.
To date, the relationship between air pollutants and venous thromboembolism (VTE) has not been well established. Our aim is to investigate the association between ambient air pollutants and the incidence of VTE using the Korean National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) database. From 2003 to 2015, 338,616 subjects from the general population not previously diagnosed with VTE were included. The long-term average concentration of air pollutants before diagnosis for each subject was calculated. During the study period, there were 3196 incident cases of VTE. After adjusting for age, gender, economic status, body mass index, physical activity, smoking, alcohol consumption, comorbid diseases, and meteorological variables, the risk of VTE was observed to increase significantly with the long-term average concentration of particulate matter < 10 μm in diameter: PM10 (hazard ratio (HR) = 1.064 (95% confidence interval [CI] 1.053−1.074) for 1 μg/m3), SO2 (HR = 1.118 (95% CI 1.079−1.158) 1 ppb), and O3 (HR = 1.039 (95% CI 1.026−1.053) for 1 ppb), respectively. A difference between the date of the health screening and the date of diagnosis of the disease was observed. Long-term exposure to air pollutants including PM10, SO2, and O3 may be an independent risk factor for the development of VTE.
迄今为止，空气污染物与静脉血栓栓塞症（VTE）之间的关系尚未明确确立。我们的目的是利用韩国国民健康保险服务-国民健康筛查队列（NHIS-HEALS）数据库，研究环境空气污染物与VTE发病率之间的关联。2003年至2015年，纳入了338,616名此前未被诊断为VTE的普通人群受试者。计算了每位受试者诊断前空气污染物的长期平均浓度。在研究期间，有3196例VTE发病病例。在调整了年龄、性别、经济状况、体重指数、身体活动、吸烟、饮酒、合并疾病和气象变量后，观察到VTE风险随直径<10μm的颗粒物（PM10）长期平均浓度显著增加：对于每立方米1微克的PM10，风险比（HR）=1.064（95%置信区间[CI]为1.053−1.074）；对于每十亿分之一体积的二氧化硫（SO2），HR = 1.118（95% CI为1.079−1.158）；对于每十亿分之一体积的臭氧（O3），HR = 1.039（95% CI为1.026−1.053）。观察到健康筛查日期与疾病诊断日期之间存在差异。长期暴露于包括PM10、SO2和O3在内的空气污染物可能是VTE发生的独立危险因素。
