De Vincenzi M, Silano M, Maialetti F, Scazzocchio B
Department of Metabolism and Pathological Biochemistry, ISS, Rome, Italy.
Fitoterapia. 2000 Dec;71(6):725-9. doi: 10.1016/s0367-326x(00)00153-2.
Estragole (ES) is a natural constituent of a number of plants (e.g. tarragon, sweet basil and sweet fennel) and their essential oils have been widely used in foodstuffs as flavouring agents. Several studies with oral, i.p. or s.c. administration to CD-1 and B6C3F1 mice have shown the carcinogenicity of ES. The 1-hydroxy metabolites are stronger hepatocarcinogens than the parent compound. Controversial results are reported for the mutagenicity of ES. However, the formation of hepatic DNA adducts in vivo and in vitro by metabolites of ES has been demonstrated.
草蒿脑（ES）是多种植物（如龙蒿、甜罗勒和甜茴香）的天然成分，其精油已作为调味剂广泛用于食品中。对CD-1和B6C3F1小鼠进行口服、腹腔注射或皮下注射的多项研究表明了ES具有致癌性。1-羟基代谢物比母体化合物具有更强的肝致癌性。关于ES的致突变性报道存在争议。然而，已证实在体内和体外ES的代谢物均可形成肝脏DNA加合物。
