Götz Mario E, Eisenreich Andreas, Frenzel Janine, Sachse Benjamin, Schäfer Bernd
German Federal Institute for Risk Assessment, Department Food Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
Plants (Basel). 2023 May 23;12(11):2075. doi: 10.3390/plants12112075.
Alkenylbenzenes are naturally occurring secondary plant metabolites. While some of them are proven genotoxic carcinogens, other derivatives need further evaluation to clarify their toxicological properties. Furthermore, data on the occurrence of various alkenylbenzenes in plants, and especially in food products, are still limited. In this review, we tempt to give an overview of the occurrence of potentially toxic alkenylbenzenes in essential oils and extracts from plants used for flavoring purposes of foods. A focus is layed on widely known genotoxic alkenylbenzenes, such as safrole, methyleugenol, and estragole. However, essential oils and extracts that contain other alkenylbenzenes and are also often used for flavoring purposes are considered. This review may re-raise awareness of the need for quantitative occurrence data for alkenylbenzenes in certain plants but especially in final plant food supplements, processed foods, and flavored beverages as the basis for a more reliable exposure assessment of alkenylbenzenes in the future.
链烯基苯是天然存在的次生植物代谢产物。虽然其中一些已被证实是具有基因毒性的致癌物，但其他衍生物需要进一步评估以阐明其毒理学特性。此外，关于各种链烯基苯在植物中，尤其是在食品中的存在数据仍然有限。在本综述中，我们试图概述用于食品调味目的的植物精油和提取物中潜在有毒链烯基苯的存在情况。重点关注广为人知的具有基因毒性的链烯基苯，如黄樟素、甲基丁香酚和草蒿脑。然而，也考虑了含有其他链烯基苯且常用于调味目的的精油和提取物。本综述可能会再次提高人们对某些植物中，尤其是最终植物性食品补充剂、加工食品和调味饮料中链烯基苯定量存在数据的需求的认识，作为未来更可靠地评估链烯基苯暴露情况的基础。
