Minoda R, Masuyama K, Habu K, Yumoto E
Department of Otolaryngology, Head Neck Surgery, Kumamoto University School of Medicine, Japan.
Am J Otol. 2000 Nov;21(6):819-25.
The purpose of this study was to clarify whether higher doses of steroids improve the prognosis of idiopathic sensorineural hearing loss (ISHL) and the suitable dose of steroid hormone.
The study was a retrospective statistical analysis.
This study was performed at the Department of Otolaryngology, Head Neck Surgery, Kumamoto University School of Medicine.
Two hundred fifty patients with ISHL were analyzed in this study. They were divided into two groups: those receiving less than a specified daily dose of steroid and those receiving a daily dose greater than or equal to the specified dose.
The patients received systemic steroid therapy combined with adenosine triphosphate, vitamins, diuretics, vasodilators, hyperbaric oxygen therapy, stellate ganglion block, or volume expander.
The correlation between the initial dose of steroid hormone and the improvement rate was analyzed.
Spearman's correlation coefficients and partial correlation coefficients between the initial dose and the prognosis were all significantly negative. On the other hand, the correlations between the initial dose and the prognosis were positive in the group receiving <30 mg/day, whereas they were negative in the group receiving > or =30 mg/day, although these correlations were not significant.
The general use of steroid hormone to treat ISHL is not recommended. Furthermore, if steroid hormone is used for treatment, the use of <30 mg/day of prednisolone is preferable.
本研究旨在阐明更高剂量的类固醇激素是否能改善特发性感音神经性听力损失（ISHL）的预后以及类固醇激素的合适剂量。
本研究为回顾性统计分析。
本研究在熊本大学医学院耳鼻咽喉头颈外科进行。
本研究分析了250例ISHL患者。他们被分为两组：接受低于特定每日剂量类固醇激素的患者和接受每日剂量大于或等于特定剂量的患者。
患者接受全身类固醇激素治疗，联合三磷酸腺苷、维生素、利尿剂、血管扩张剂、高压氧治疗、星状神经节阻滞或扩容剂。
分析类固醇激素初始剂量与改善率之间的相关性。
初始剂量与预后之间的Spearman相关系数和偏相关系数均显著为负。另一方面，在接受<30mg/天的组中，初始剂量与预后之间的相关性为正，而在接受≥30mg/天的组中，相关性为负，尽管这些相关性不显著。
不建议常规使用类固醇激素治疗ISHL。此外，如果使用类固醇激素进行治疗，泼尼松龙每日用量<30mg更佳。
