Suzuki Hideaki, Fujimura Takeyuki, Shiomori Teruo, Ohbuchi Toyoaki, Kitamura Takuro, Hashida Koichi, Udaka Tsuyoshi
Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Auris Nasus Larynx. 2008 Jun;35(2):192-7. doi: 10.1016/j.anl.2007.06.003. Epub 2007 Sep 10.
We conducted a controlled retrospective analysis of patients with idiopathic sudden sensorineural hearing loss (ISSNHL) in order to investigate the effect of prostaglandin E1 (PGE1) plus hyperbaric oxygen (HBO) therapy in comparison with that of steroid plus HBO therapy.
One hundred and ninety-six consecutive patients with ISSNHL (hearing levels > or ==40dB; time from the onset of hearing loss to the start of treatment < or ==30 days) were enrolled. Ninety-five patients underwent PGE1 plus HBO therapy (PG group) and 101 underwent steroid administration plus HBO therapy (steroid group). Hearing recovery was evaluated by grade assessment and by the improvement in hearing compared to the unaffected contralateral ear.
The hearing levels after treatment were 52.2+/-3.0 and 47.5+/-2.8dB, the hearing gains were 31.3+/-2.2 and 27.2+/-2.3dB, the cure rates were 28.4% and 28.7%, the recovery rates were 54.7% and 53.5%, and the hearing improvement rates were 48.4+/-5.1% and 53.9+/-4.2% in the PG and steroid groups, respectively. There were no significant differences between the two groups.
We concluded that PGE1 and a steroid are equally effective in the treatment of ISSNHL when used together with HBO therapy. PGE1 plus HBO therapy can be one of the potential alternative treatments for ISSNHL, particularly in steroid-intolerant patients such as those with severe diabetes mellitus, an active peptic ulcer, or viral hepatitis.
我们对特发性突发性感音神经性听力损失（ISSNHL）患者进行了对照回顾性分析，以研究前列腺素E1（PGE1）联合高压氧（HBO）治疗与类固醇联合HBO治疗的效果对比。
纳入196例连续的ISSNHL患者（听力水平>或==40dB；从听力损失发作到开始治疗的时间<或==30天）。95例患者接受PGE1联合HBO治疗（PG组），101例患者接受类固醇给药联合HBO治疗（类固醇组）。通过分级评估以及与未受影响的对侧耳相比的听力改善情况来评估听力恢复情况。
PG组和类固醇组治疗后的听力水平分别为52.2±3.0和47.5±2.8dB，听力增益分别为31.3±2.2和27.2±2.3dB，治愈率分别为28.4%和28.7%，恢复率分别为54.7%和53.5%，听力改善率分别为48.4±5.1%和53.9±4.2%。两组之间无显著差异。
我们得出结论，PGE1和类固醇与HBO治疗联合使用时，在治疗ISSNHL方面同样有效。PGE1联合HBO治疗可以成为ISSNHL的潜在替代治疗方法之一，特别是对于类固醇不耐受的患者，如患有严重糖尿病、活动性消化性溃疡或病毒性肝炎的患者。
