血管紧张素转换酶基因与汉族晚发性阿尔茨海默病之间的关联。
Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese.
作者信息
Yang J D, Feng G, Zhang J, Lin Z X, Shen T, Breen G, St Clair D, He L
机构信息
Bio-X Life Science Research Center, Shanghai Jiao Tong University, 200030, People's Republic of, Shanghai, China.
出版信息
Neurosci Lett. 2000 Dec 1;295(1-2):41-4. doi: 10.1016/s0304-3940(00)01591-3.
There is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (I/D) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR)=2.09, P=0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P<0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD.
目前有压倒性的证据表明，载脂蛋白（APOE）基因的ε4等位基因是晚发性阿尔茨海默病（AD）的主要危险因素。然而，APOE基因座仅占AD总体遗传风险的一部分。血管紧张素转换酶（ACE）在大脑中广泛表达，可能在AD中起作用。最近发现，ACE基因内含子16处的插入/缺失（I/D）DNA多态性与晚发性AD相关，但结果并不一致。我们在一组汉族AD病例和对照中检测了ACE基因。我们发现，与对照组相比，ACE-I等位基因在我们的病例中更为富集（优势比（OR）=2.09，P=0.0043）。这种现象仅限于70岁以后出现AD的病例（P<0.0005），且与APOE基因型无关。我们得出结论，ACE基因型是晚发性AD的一个危险因素。
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