Wang H K, Fung H C, Hsu W C, Wu Y R, Lin J C, Ro L S, Chang K H, Hwu F J, Hsu Y, Huang S Y, Lee-Chen G J, Chen C M
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.
J Neural Transm (Vienna). 2006 Oct;113(10):1499-509. doi: 10.1007/s00702-005-0424-z. Epub 2006 Feb 9.
Lipoproteins and vascular factors may play roles in the development of Alzheimer's disease (AD) and/or vascular dementia (VaD). In this study, odd ratios (ORs) and 95% confidence intervals (CIs) for apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and kallikrein (KLK1) polymorphisms were computed to test their association with the disease by a case-control study. The risk of AD was significantly increased for individuals with APOE varepsilon4 allele (OR = 3.73, 95% CI = 2.38-5.98). The risk of AD was also significant for people with ACE DD genotype, D allele, or T-D haplotype [OR (95% CI) = 4.29 (1.96-10.23), 1.90 (1.35-2.70), or 2.91 (1.71-5.10), respectively]. The above association between ACE-VaD was also strong (p = 0.0012, 0.0050, 0.0007, respectively). Reporter constructs containing the -240 A or T allele displayed similar transcriptional activity in both HEK-293 and IMR-32 cells. Thus, another putative pathogenic marker that is linked with the Alu D allele might affect the risk of AD and VaD in Taiwan.
脂蛋白和血管因子可能在阿尔茨海默病（AD）和/或血管性痴呆（VaD）的发展中起作用。在本研究中，计算了载脂蛋白E（APOE）、血管紧张素转换酶（ACE）和激肽释放酶（KLK1）多态性的比值比（OR）和95%置信区间（CI），通过病例对照研究来检验它们与疾病的关联。携带APOE ε4等位基因的个体患AD的风险显著增加（OR = 3.73，95% CI = 2.38 - 5.98）。ACE DD基因型、D等位基因或T - D单倍型的个体患AD的风险也显著[OR（95% CI）分别为4.29（1.96 - 10.23）、1.90（1.35 - 2.70）或2.91（1.71 - 5.10）]。ACE与VaD之间的上述关联也很强（p分别为0.0012、0.0050、0.0007）。含有 - 240 A或T等位基因的报告基因构建体在HEK - 293和IMR - 32细胞中均表现出相似的转录活性。因此，另一个与Alu D等位基因相关的假定致病标志物可能会影响台湾地区AD和VaD的风险。
