Chua K B, Lam S K, Tan C T, Hooi P S, Goh K J, Chew N K, Tan K S, Kamarulzaman A, Wong K T
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Ann Neurol. 2000 Nov;48(5):802-5.
During the outbreak of Nipah virus encephalitis in Malaysia, stored cerebrospinal fluid (CSF) samples from 84 patients (27 fatal and 57 nonfatal cases) were cultured for the virus. The virus was isolated from 17 fatal cases and 1 nonfatal case. There were significant associations between CSF virus isolation and mortality as well as clinical features associated with poor prognosis. In addition, there was a positive linear correlation of CSF virus isolation with age. There was no significant association between CSF virus isolation and the character of the CSF, presence of Nipah-specific antibody in the serum or CSF, duration of illness before collection of samples, or sex or ethnicity of the patients. This study suggests that high viral replication in the central nervous system may be an important factor for high mortality.
在马来西亚尼帕病毒脑炎疫情爆发期间，对84例患者（27例死亡病例和57例非死亡病例）的储存脑脊液（CSF）样本进行了病毒培养。从17例死亡病例和1例非死亡病例中分离出了病毒。脑脊液病毒分离与死亡率以及预后不良相关的临床特征之间存在显著关联。此外，脑脊液病毒分离与年龄呈正线性相关。脑脊液病毒分离与脑脊液特征、血清或脑脊液中尼帕特异性抗体的存在、样本采集前的病程、患者的性别或种族之间均无显著关联。这项研究表明，中枢神经系统中的高病毒复制可能是高死亡率的一个重要因素。
