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西莫环素，由抗生链霉菌Tü 6040产生的新型细胞生长抑制型蒽环类抗生素。I. 分类学、发酵、分离及生物活性

Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities.

作者信息

Schimana J, Fiedler H P, Groth I, Süssmuth R, Beil W, Walker M, Zeeck A

机构信息

Mikrobiologisches Institut, Universität Tübingen, Germany.

出版信息

J Antibiot (Tokyo). 2000 Aug;53(8):779-87. doi: 10.7164/antibiotics.53.779.

DOI:10.7164/antibiotics.53.779
PMID:11079799
Abstract

Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

摘要

通过高效液相色谱-二极管阵列检测法和高效液相色谱-电喷雾质谱筛查法，在抗生链霉菌Tü 6040的菌丝体提取物中检测到两种新型安古洛环酮类抗生素，即西莫环素D4和D8。这些化合物对革兰氏阳性菌具有抗菌活性，并对多种肿瘤细胞系具有细胞抑制作用。

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