Holzenkämpfer Meike, Walker Martina, Zeeck Axel, Schimana Judith, Fiedler Hans-Peter
Institut für Organische Chemie, Universität Göttingen, Germany.
J Antibiot (Tokyo). 2002 Mar;55(3):301-7. doi: 10.7164/antibiotics.55.301.
The simocyclinones D4 (1) and D8 (2), members of a novel class of antibiotics, were isolated from the mycelial extract of Streptomyces antibioticus Tü 6040 and consist of angucyclinone, deoxysugar, octatetraene dicarboxylate and aminocoumarin structural elements. The structure elucidation was done by one and two dimensional NMR experiments, and other spectroscopic methods in combination with incorporation experiments using 13C labelled precursors.
