Hedin K, Babic A, Frydén A
Department of Infectious Diseases, Linköping University Hospital, Sweden.
Proc AMIA Symp. 2000:340-3.
The severity of chronic hepatitis C infection in the individual patient is monitored using blood laboratory findings and liver biopsy. If blood test results could be shown to provide sufficient information concerning the disease, the invasive procedure of liver biopsy could perhaps be avoided in some instances. This study assessed the clinical relevance of blood laboratory tests for detecting disease-related changes in the liver. Histopathological classification was used to assign class membership of the patients and data mining operations were performed in an elaborate way on 19 different data sets. Disease activity could be detected by a small set of blood tests. Extended sets could identify more severe changes, but failed to distinguish them. The extracted rules are implemented as a part of the knowledge base of a corresponding decision support system aimed at specialists and general practitioners.
通过血液实验室检查结果和肝活检来监测个体患者慢性丙型肝炎感染的严重程度。如果血液检测结果能够提供有关该疾病的足够信息，那么在某些情况下或许可以避免肝活检这种侵入性操作。本研究评估了血液实验室检查对于检测肝脏疾病相关变化的临床相关性。采用组织病理学分类来确定患者的类别归属，并对19个不同的数据集进行了精细的数据挖掘操作。通过一小部分血液检测能够检测出疾病活动情况。扩展的检测组合能够识别出更严重的变化，但无法将它们区分开来。提取的规则作为相应决策支持系统知识库的一部分来实施，该系统面向专科医生和全科医生。
