Dhillon A P, Dusheiko G M
University Department of Histopathology, Royal Free Hospital School of Medicine, London, UK.
Histopathology. 1995 Apr;26(4):297-309. doi: 10.1111/j.1365-2559.1995.tb00191.x.
This paper reviews our current knowledge of hepatitis C virus, its structure, epidemiology and pathological effects in man. The histopathological features of acute and chronic hepatitis due to hepatitis C virus are detailed and illustrated. The possible pathogenetic mechanisms involved in the liver injury are outlined and the significance of genotypic subtypes of the virus and of host genetic predisposition in relation to the liver injury and the response to therapy are summarized.
本文综述了我们目前对丙型肝炎病毒的认识，包括其结构、流行病学及对人类的病理影响。详细阐述并举例说明了丙型肝炎病毒所致急性和慢性肝炎的组织病理学特征。概述了肝脏损伤可能涉及的发病机制，并总结了病毒基因亚型及宿主遗传易感性与肝脏损伤和治疗反应的相关性。
