Ayada K, Watanabe M, Endo Y
Department of Geriatric Dentistry, School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Am J Physiol Regul Integr Comp Physiol. 2000 Dec;279(6):R2042-7. doi: 10.1152/ajpregu.2000.279.6.R2042.
The effects of different types of stress (water bathing, cold, restraint, and prolonged walking) on histidine decarboxylase (HDC) activity in masseter, quadriceps femoris, and pectoralis superficial muscles, and in the stomach were examined in mice. All of these stresses elevated gastric HDC activity. Although water bathing, in which muscle activity was slight, was sufficiently stressful to produce gastric hemorrhage and to increase gastric HDC activity, it produced no detectable elevation of HDC activity in any of the muscles examined. The other stresses all elevated HDC activity in all three muscles. We devised two methods of restraint, one accompanied by mastication and the other not. The former elevated HDC activity in the masseter muscle, but the latter did not. These results suggest that 1) HDC activity in the stomach is an index of responses to stress, 2) the elevation of HDC activity in skeletal muscles during stress is induced partly or wholly by muscle activity and/or muscle tension, and 3) stress itself does not always induce an elevation of HDC activity in skeletal muscles.
研究了不同类型应激（水浴、寒冷、束缚和长时间行走）对小鼠咬肌、股四头肌、胸浅肌以及胃中组氨酸脱羧酶（HDC）活性的影响。所有这些应激均提高了胃HDC活性。尽管水浴时肌肉活动轻微，但它产生的应激足以导致胃出血并增加胃HDC活性，然而在所检测的任何肌肉中，它均未使HDC活性出现可检测到的升高。其他应激均提高了所有这三块肌肉中的HDC活性。我们设计了两种束缚方法，一种伴有咀嚼，另一种则没有。前者使咬肌中的HDC活性升高，而后者则没有。这些结果表明：1）胃中的HDC活性是应激反应的一个指标；2）应激期间骨骼肌中HDC活性的升高部分或全部是由肌肉活动和/或肌肉张力诱导的；3）应激本身并不总是会导致骨骼肌中HDC活性升高。
