异体细胞和效应细胞对体外抗体产生细胞发育的影响。
Effects of allogenic and effector cells on the development of antibody-producing cells, in vitro.
作者信息
Pazdernik T L, Uyeki D M
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):654-9. doi: 10.3181/00379727-150-39099.
Effects of allogenic and effector spleen cells on the development of anti-SRBC plaque-forming cells from target spleen cells in vitro were studied. Addition of allogeneic cells resulted in various degrees of suppression of target cell PFC production. This allogeneic suppression could be abolished by pretreating the cells with either uv or X irradiation. Addition of effector cells to target spleen cell cultures markedly suppressed PFC production. Effector cell suppression of PFC production was anti-BAtheta serum-sensitive and radiation-resistant.
研究了同种异体脾细胞和效应脾细胞对体外靶脾细胞抗绵羊红细胞（SRBC）斑块形成细胞（PFC）发育的影响。添加同种异体细胞导致靶细胞PFC产生受到不同程度的抑制。这种同种异体抑制可通过用紫外线（uv）或X射线照射预处理细胞来消除。向靶脾细胞培养物中添加效应细胞可显著抑制PFC产生。效应细胞对PFC产生的抑制对抗BAθ血清敏感且对辐射有抗性。
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