Santanello N C, Demuro-Mercon C, Davies G, Ostrom N, Noonan M, Rooklin A, Knorr B
Merck Research Laboratories, West Point; the Allergy & Asthma Medical Group and Research Center, San Diego, CA, USA.
J Allergy Clin Immunol. 2000 Nov;106(5):861-6. doi: 10.1067/mai.2000.110478.
Young children are generally not able to consistently and reliably perform tests of airway function, and normative values are not available. Reliable and valid measures of parental reporting of asthma symptoms and functioning are needed to determine the efficacy of asthma interventions.
A pediatric asthma caregiver diary was developed and validated for use in interventional asthma studies.
A 3-week prospective study of 125 caregiver parents and their children, aged 2 to 5 years, with persistent asthma was conducted. At baseline, children were classified as either stable (no change to anti-inflammatory therapy) or unstable (anti-inflammatory therapy added or increased).
A symptom scale and day without asthma symptoms (DWAS) were defined from pediatric asthma caregiver diary questions. The scale and DWAS statistically differentiated between the stable and unstable groups at week 1 and detected change between the 2 groups (P <.01). On average, caregivers reported low symptom scores. However, the frequency of DWAS was only 43% of days in the stable group and 22% in the unstable group.
The pediatric asthma caregiver diary scale and DWAS have acceptable measurement characteristics for use in clinical trials of children with asthma symptoms. The DWAS indicates an opportunity for improvement in asthma control in this population.
幼儿通常无法持续且可靠地进行气道功能测试，并且尚无规范值。需要可靠且有效的措施来让家长报告哮喘症状及功能情况，以确定哮喘干预措施的疗效。
开发并验证一种用于哮喘干预研究的儿科哮喘照护者日记。
对125名照护者家长及其2至5岁患有持续性哮喘的孩子进行了一项为期3周的前瞻性研究。在基线时，将儿童分为稳定组（抗炎治疗无变化）或不稳定组（添加或增加抗炎治疗）。
根据儿科哮喘照护者日记中的问题定义了症状量表和无哮喘症状天数（DWAS）。该量表和DWAS在第1周时在稳定组和不稳定组之间有统计学差异，并检测到两组之间的变化（P<.01）。平均而言，照护者报告的症状评分较低。然而，稳定组中DWAS的天数频率仅为43%，不稳定组为22%。
儿科哮喘照护者日记量表和DWAS在哮喘症状儿童的临床试验中具有可接受的测量特征。DWAS表明该人群在哮喘控制方面有改善的机会。
