Giles R W, Eikens E, Paoloni H J, Glover W E, Wilcken D E
Cardiovasc Res. 1975 Nov;9(6):779-87. doi: 10.1093/cvr/9.6.779.
Intracoronary administration of isoprenaline, adrenaline, and the noradrenaline in the Langendorff-type transplanted dog heart transiently decreased coronary blood flow measured from the inflow vessel; flow then increased. The reduction in coronary flow coincided with increased myocardial contractility and was prevented by keeping the left ventricle empty. Propranolol prevented changes in flow and contractility. It is concluded that positive inotropic changes result in the ejection of accumulated Thesbesian flow from the ventricle and affect coronary flow measurements and that the interpretation of flow changes requires a steady state.
在兰根多夫型移植犬心脏中冠状动脉内注射异丙肾上腺素、肾上腺素和去甲肾上腺素，可使从流入血管测得的冠状动脉血流量短暂减少，随后血流量增加。冠状动脉血流量的减少与心肌收缩力增强同时出现，并且通过使左心室保持空虚可防止这种情况发生。普萘洛尔可防止血流量和收缩力的变化。得出的结论是，正性肌力变化导致心室中积聚的心最小静脉血流排出，影响冠状动脉血流量测量，并且血流量变化的解释需要一个稳定状态。
