褪黑素对新生儿垂体对促黄体生成素释放因子反应的抑制作用。
Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor.
作者信息
Martin J E, Klein D C
出版信息
Science. 1976 Jan 23;191(4224):301-2. doi: 10.1126/science.1108199.
PMID:1108199
Abstract
Neonatal rat anterior pituitary glands treated in organ culture with 1 nanomolar luteinzing hormone-releasing factor (LRF) showed a tenfold increase in medium luteinizing hormone (LH) concentrations over control values. Simultaneous treatment of the glands with 1 nanomolar melatonin significantly reduced the stimulatory effect of LRF on release of LH. This finding indicates that melatonin can act directly on the neonatal pituitary to inhibit the LH response to LRF.
摘要
用1纳摩尔促黄体生成素释放因子（LRF）进行器官培养处理的新生大鼠垂体前叶，其培养基中促黄体生成素（LH）浓度比对照值增加了10倍。同时用1纳摩尔褪黑素处理这些腺体，显著降低了LRF对LH释放的刺激作用。这一发现表明，褪黑素可直接作用于新生垂体，抑制LH对LRF的反应。
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