Hussain S P, Hollstein M H, Harris C C
Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA.
Ann N Y Acad Sci. 2000;919:79-85. doi: 10.1111/j.1749-6632.2000.tb06870.x.
The molecular archaeology of the mutation spectra of tumor suppressor genes generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the p53 gene implicates environmental carcinogens and both endogenous agents and processes in the etiology of human cancer.
肿瘤抑制基因突变谱的分子考古学为人类癌症的病因和分子发病机制提出了假设。p53基因的体细胞突变谱表明环境致癌物以及内源性因素和过程在人类癌症病因中发挥作用。
