Truitt R L, Pollard M
Transplantation. 1976 Jan;21(1):12-6. doi: 10.1097/00007890-197601000-00003.
"Hodgkin's-like reticulum cell sarcoma develops spontaneously in most SJL mice. Germ-free and conventional SJL mice bearing advanced reticulum cell sarcoma were treated with X-irradiation and transplantation of bone marrow from SJL or C3H/He donors. The 120-day survival rate of germ-free mice receiving allogeneic bone marrow (70%) exceeded that of all control groups; more importantly, germ-free mice that survived more than 4 months after treatment with allogeneic cells had no evidence of neoplastic lesions when killed. The germ-free environment effectively prevented graft-versus-host disease that was lethal to conventional mice. The results of these experiments offer additional evidence that bone marrow transplantation can be used as a therapeutic tool for spontaneous murine neoplasms.
霍奇金样网状细胞肉瘤在大多数SJL小鼠中自发产生。对患有晚期网状细胞肉瘤的无菌和常规SJL小鼠进行X射线照射，并移植来自SJL或C3H/He供体的骨髓。接受异基因骨髓的无菌小鼠的120天生存率（70%）超过了所有对照组；更重要的是，用异基因细胞治疗后存活超过4个月的无菌小鼠在处死时没有肿瘤病变的迹象。无菌环境有效地预防了对常规小鼠致命的移植物抗宿主病。这些实验结果提供了额外的证据，证明骨髓移植可作为自发性小鼠肿瘤的一种治疗工具。
