Schwille P O, Brandt G, Brunner P, Ulbrich D, Kömpf W
Urologe A. 1975 Nov;14(6):306-14.
Rats fed abnormally composed isocaloric diets during 21 days (low magnesium, atherogenous, high in proteins or carbohydrates) develop a mean increase in total number of pancreatic A cells, a significant increase of A/B ratio (atherogenous), and hyperglucagonemia in most of the groups under study. Histologic examination reveals calcification most marked in animals under low magnesium and atherogenous diets. They are only scarce following high protein diet; a normal or carbohydrate rich diet nullifies this phenomenon. Independent of the morphologic and functional state of the islets, supplementation by argining and histidine of normal chow is followed by a certain degree of renal calcification. Lowered urinary magnesium and calcium and elevated urinary sodium and phosphate together with a tendency toward hypercalcemia point to stimulation of parathyroids during malnutrition. Absolute or relative hyperglucagonemia must be considered the main causstive factor.
给大鼠喂食营养成分异常的等热量饮食21天（低镁、致动脉粥样硬化、高蛋白或高碳水化合物饮食），在大多数研究组中，胰腺A细胞总数平均增加，A/B比值显著升高（致动脉粥样硬化饮食组），并出现高胰高血糖素血症。组织学检查显示，低镁饮食组和致动脉粥样硬化饮食组动物的钙化最为明显。高蛋白饮食组仅出现少量钙化；正常饮食或富含碳水化合物的饮食可消除这种现象。无论胰岛的形态和功能状态如何，在正常食物中补充精氨酸和组氨酸后会出现一定程度的肾钙化。尿镁和钙降低，尿钠和磷酸盐升高，同时伴有高钙血症倾向，表明营养不良期间甲状旁腺受到刺激。必须将绝对或相对高胰高血糖素血症视为主要致病因素。
