Linnemann U, Kuch P, Schwille P O
Urol Res. 1986;14(6):319-22. doi: 10.1007/BF00262383.
In the male rat the effects of portocaval shunt (PCS) on mineral metabolism (fractional intestinal absorption, minerals in serum, in bone, in kidney, and in urine) and the effects on urinary constituents were studied. PCS induced a degree of hyperparathyroidism and the formation of ammonium acid urate urinary tract stones. These phenomena were associated with elevated uric acid, ammonium, urinary pH, as well as with elevated supersaturation of urine with struvite, and to a lesser degree with ammonium acid urate. It is suggested that in the rat PCS interferes with both parathyroid gland function and urinary nucleation of ammonium acid urate.
在雄性大鼠中，研究了门腔静脉分流术（PCS）对矿物质代谢（小肠吸收分数、血清、骨骼、肾脏和尿液中的矿物质）的影响以及对尿液成分的影响。PCS导致了一定程度的甲状旁腺功能亢进和尿酸铵尿路结石的形成。这些现象与尿酸、铵、尿液pH值升高以及磷酸镁铵导致的尿液过饱和度升高有关，在较小程度上与尿酸铵有关。研究表明，在大鼠中，PCS会干扰甲状旁腺功能和尿酸铵的尿液成核过程。
