Sayeg Porto M A, Oliveira H P, Cunha A J, Miranda G, Guimarães M M, Oliveira W A, dos Santos D M
Pediatric Endocrinology Department Martagão Gesteira Child Care and Pediatrics Institute (IPPMG), Federal University in Rio de Janeiro, Brazil.
J Pediatr Endocrinol Metab. 2000 Sep-Oct;13(8):1121-8. doi: 10.1515/jpem.2000.13.8.1121.
Physical growth retardation is an early and prominent feature of zinc deficiency, but the effect of zinc supplementation in children is still not completely clear. This study investigated the impact of zinc supplementation on linear growth, growth velocity, IGF-I levels, and skeletal maturation of short children during and after mineral supplementation. The study was designed as a double-blind, randomized, controlled trial of zinc supplementation during a 6-month period, with a subsequent 6-month follow-up. Anthropometric data were collected at 0, 6, and 12 months. Measurements included plasma Zn, IGF-I, height, weight, triceps skinfold thickness, and body mass index. Eighteen healthy pre-pubertal short children (z-score -2.0) 7 to 10 years old with normal GH and IGF-I levels were randomized to two groups, one with zinc supplementation (5 mg/kg/d of ZnSO4) and the other with placebo. In the first 6 months, only height velocity increased significantly, 5.99+/-0.80 cm/yr vs 5.05+/-0.85 cm/yr (p=0.03). After 12 months, height velocity returned to the initial values, 3.92+/-0.59 cm/yr vs 4.19+/-1.08 cm/yr (p=0.29). This study indicates that zinc supplementation increased growth velocity, but these effects did not persist after supplementation was discontinued.
身体生长发育迟缓是锌缺乏的一个早期且突出的特征，但锌补充剂对儿童的影响仍不完全清楚。本研究调查了锌补充剂对矿物质补充期间及之后矮小儿童的线性生长、生长速度、胰岛素样生长因子-I（IGF-I）水平和骨骼成熟度的影响。该研究设计为一项为期6个月的锌补充剂双盲、随机、对照试验，并随后进行6个月的随访。在0、6和12个月时收集人体测量数据。测量指标包括血浆锌、IGF-I、身高、体重、肱三头肌皮褶厚度和体重指数。18名7至10岁健康的青春期前矮小儿童（z评分-2.0），生长激素（GH）和IGF-I水平正常，被随机分为两组，一组补充锌（硫酸锌5mg/kg/天），另一组服用安慰剂。在最初的6个月里，只有身高增长速度显著增加，分别为5.99±0.80厘米/年和5.05±0.85厘米/年（p=0.03）。12个月后，身高增长速度恢复到初始值，分别为3.92±0.59厘米/年和4.19±1.08厘米/年（p=0.29）。本研究表明，锌补充剂可提高生长速度，但在停止补充后这些效果并未持续。
