Castillo-Durán C, García H, Venegas P, Torrealba I, Panteón E, Concha N, Pérez P
Department of Pediatrics, Dr Sótero del Rio Hospital, Santiago, Chile.
Acta Paediatr. 1994 Aug;83(8):833-7. doi: 10.1111/j.1651-2227.1994.tb13154.x.
We assessed the effect of zinc supplementation on growth velocity in 79 children and adolescents (48 males, 38 females) with idiopathic short stature. Their height-for-age was < 5th percentile (NCHS standards) and their weight-for-age was normal. Patients were assigned randomly to a supplemented group (S) to receive Zn 10 mg/day or to a placebo (P) group, according to gender and age, and were followed-up for 12 months using a double-blind design. Weight, height, armspan, length of lower segment and plasma and hair concentrations of Zn were measured at 0, 3, 6 and 12 months. On admission and at 6 months, energy, protein, dietary fiber and zinc intakes were similar for groups S and P; mean zinc intake was < 6.5 mg/day. No differences were found in plasma zinc, hair zinc, weight, armspan or lower segment increments. Pre-adolescent males in group S had a significantly greater increase in stature compared with group P (6.2 +/- 2.1 versus 4.5 +/- 1.2 cm/year p < 0.025); z score improved from -2.42 to -2.24 in group S and from -2.63 to -2.61 in group P. For adolescent males, the difference was also significant (8.3 +/- 1.5 versus 6.2 +/- 2.1 cm/year; p < 0.025). No differences were noted in females. In Chilean male schoolchildren and adolescents with idiopathic short stature, zinc supplementation increases growth velocity over a 12-month period.
我们评估了补锌对79名患有特发性身材矮小的儿童和青少年（48名男性，38名女性）生长速度的影响。他们的年龄别身高低于第5百分位数（美国国家卫生统计中心标准），但年龄别体重正常。根据性别和年龄，将患者随机分为补锌组（S组），每天服用10毫克锌，或安慰剂（P组），采用双盲设计进行为期12个月的随访。在0、3、6和12个月时测量体重、身高、臂展、下肢长度以及血浆和头发中的锌浓度。入院时和6个月时，S组和P组的能量、蛋白质、膳食纤维和锌摄入量相似；平均锌摄入量低于6.5毫克/天。血浆锌、头发锌、体重、臂展或下肢增长方面未发现差异。S组青春期前男性的身高增长显著高于P组（6.2±2.1对4.5±1.2厘米/年，p<0.025）；S组的z评分从-2.42提高到-2.24，P组从-2.63提高到-2.61。对于青春期男性，差异也显著（8.3±1.5对6.2±2.1厘米/年；p<0.025）。女性未发现差异。在智利患有特发性身材矮小的男学生和青少年中，补锌可在12个月内提高生长速度。
