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[不同感染敏感性动物兔热病中性粒细胞的吞噬活性]

[Phagocytic activity of the neutrophils in tularemia in animals with varying infective sensitivity].

作者信息

Dunaeva T N, Shlygina K N

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1975 Oct(10):22-6.

PMID:1108522
Abstract

A study was made of the ingestive capacity of blood neutrophils; there were revealed no significant differences in the intact animals with a different infectious sensitivity to tularemia. With the development of infection the ingestive activity of leukocytes increased in the infected highly sensitive animals, but the digestive function was not manifest. In albino rats (with a low sensitivity to tularemia) the disease induced an intensification of the ingestive and the manifestation of the digestive function of neutrophils dynamically developing together with the specific immunity reactions.

摘要

对血液中性粒细胞的吞噬能力进行了一项研究;结果显示,对土拉菌病具有不同感染敏感性的健康动物之间没有显著差异。随着感染的发展,感染的高敏动物中白细胞的吞噬活性增加,但消化功能未表现出来。在白化大鼠(对土拉菌病敏感性低)中,疾病引起吞噬作用增强,并且中性粒细胞的消化功能表现与特异性免疫反应一起动态发展。

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引用本文的文献

1
Multifaceted effects of Francisella tularensis on human neutrophil function and lifespan.土拉弗朗西斯菌对人中性粒细胞功能和寿命的多方面影响。
Immunol Rev. 2016 Sep;273(1):266-81. doi: 10.1111/imr.12445.
2
Neutrophils: potential therapeutic targets in tularemia?中性粒细胞:土拉菌病的潜在治疗靶点?
Front Cell Infect Microbiol. 2013 Dec 27;3:109. doi: 10.3389/fcimb.2013.00109. eCollection 2013.
3
Alpha-1 antitrypsin is markedly decreased following pulmonary F. tularensis challenge.甲型 1 抗胰蛋白酶在肺部感染土拉弗朗西斯菌后明显减少。
Front Cell Infect Microbiol. 2011 Dec 26;1:20. doi: 10.3389/fcimb.2011.00020. eCollection 2011.
4
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis.A型和 B 型土拉弗朗西斯菌 NADPH 氧化酶抑制的多种机制。
J Leukoc Biol. 2010 Oct;88(4):791-805. doi: 10.1189/jlb.1209811. Epub 2010 Jul 7.