Carroll S, Cooke C B, Butterly R J
School of Leisure and Sports Studies, Leeds Metropolitan University, UK.
Blood Coagul Fibrinolysis. 2000 Oct;11(7):609-16. doi: 10.1097/00001721-200010000-00004.
The association of lifestyle factors and biochemical variables with plasma viscosity was examined in a sample of middle-aged males of high social status. Analyses were performed on a subsample of men that had relevant rheological and biochemical variables determined during a preventive medical assessment conducted between 1992 and 1996. Among 622 subjects (64 smokers), measures of physical activity or predicted VO2max and adiposity (sum of subcutaneous skinfolds) were the lifestyle factors significantly associated with plasma viscosity (both P < 0.001). Among the biochemical variables, serum total protein and plasma fibrinogen concentrations accounted for most of the explained variability in plasma viscosity within subjects (combined adjusted r2 = 65.5%). Logarithm-transformed triglyceride, leukocyte count and serum globulin together contributed an additional 3.0% of the variance in plasma viscosity. Serum total protein, In triglycerides and leukocyte count decreased significantly across higher quartiles of predicted VO2max (all P < 0.0001), with trends towards lower fibrinogen and globulin concentrations (P = 0.054 and P = 0.050, respectively). Higher levels of adiposity were also significantly associated with higher levels of serum total protein (P < 0.0001), globulin (P < 0.0001), fibrinogen (P < 0.01), leukocyte count (P < 0.05), and triglycerides (P < 0.0001). The association of lifestyle factors with the biochemical predictors of plasma viscosity may result directly from a pro-inflammatory state of adipose tissue origin and/or a larger plasma volume related to higher levels of cardiorespiratory fitness. Randomised controlled trials of the effects of regular physical activity of different intensities on plasma viscosity, with reference to body composition, are now required.
在一个高社会地位的中年男性样本中，研究了生活方式因素和生化变量与血浆粘度之间的关联。对1992年至1996年期间进行预防性医学评估时测定了相关流变学和生化变量的男性子样本进行了分析。在622名受试者（64名吸烟者）中，身体活动量或预测的最大摄氧量以及肥胖程度（皮下褶厚度总和）是与血浆粘度显著相关的生活方式因素（两者P<0.001）。在生化变量中，血清总蛋白和血浆纤维蛋白原浓度解释了受试者血浆粘度变异的大部分（综合调整后r2=65.5%）。对数转换后的甘油三酯、白细胞计数和血清球蛋白共同解释了血浆粘度变异的另外3.0%。随着预测最大摄氧量四分位数的升高，血清总蛋白、甘油三酯和白细胞计数显著降低（均P<0.0001），纤维蛋白原和球蛋白浓度有降低趋势（分别为P=0.054和P=0.050）。较高的肥胖程度也与较高的血清总蛋白（P<0.0001）、球蛋白（P<0.0001）、纤维蛋白原（P<0.01）、白细胞计数（P<0.05）和甘油三酯水平（P<0.0001）显著相关。生活方式因素与血浆粘度生化预测指标之间的关联可能直接源于脂肪组织来源的促炎状态和/或与较高心肺适能水平相关的较大血浆量。现在需要针对不同强度的规律体育活动对血浆粘度的影响进行随机对照试验，并参考身体成分。
