Carroll S, Cooke C B, Butterly R J
School of Leisure and Sports Studies, Leeds Metropolitan University, UK.
Blood Coagul Fibrinolysis. 2000 Jan;11(1):71-8.
The association between both plasma viscosity and fibrinogen concentration with clustering of metabolic risk markers was examined within a cross-sectional study of employed middle-aged men. Analyses were performed on a subsample of 629 non-smokers (46.7+/-7.8 years) without diabetes. The effect of obesity and cardiorespiratory fitness on these haemorheological parameters and their association with the metabolic syndrome was also investigated. The cohort was grouped by the number of metabolic markers present. Metabolic markers included high-density lipoprotein-cholesterol (<1.13 mmol/l), triglycerides (> or =1.805 mmol/l), glucose (> or =5.5 mmol/l) and diastolic blood pressure (> or =90 mm Hg). The age-adjusted odds ratio for hyperviscosity (> or =1.67 mPa/s) was 2.08 [95% confidence interval (CI), 1.06-4.05; P = 0.031] for the subjects with the metabolic syndrome (three or more metabolic markers) when compared with those with no metabolic abnormalities. The comparable age-adjusted odds ratio for hyperfibrinogenaemia (> or = 3.47 g/l) was non-significantly higher at 1.69 (95% CI, 0.87-3.27; P = 0.119). The mean age-adjusted plasma viscosity level and the prevalence of hyperviscosity increased significantly from 1.629 to 1.692 mPa/s (P = 0.0005) and from 21.0 to 36.0% with accumulating metabolic markers (P = 0.006). Plasma viscosity and fibrinogen concentration both increased with higher quartiles of skinfolds (P = 0.003 and P = 0.01, respectively) following adjustment for age, lipids and leucocyte count. Plasma viscosity was also significantly lower with higher levels of predicted maximum oxygen consumption (VO2max) (P = 0.0005). The odds ratio for hyperviscosity in subjects with the metabolic syndrome as compared with those with no metabolic markers was attenuated following adjustment for age, sum of skinfolds and predicted maximum oxygen consumption (VO2max) (1.44; 95% CI, 0.72-2.90; P = 0.307). These cross-sectional results suggest that plasma viscosity is associated with increased clustering of metabolic markers in middle-aged men of high socio-economic status. Obesity and poor cardiorespiratory fitness may be important in the development of haemorheological abnormalities associated with the metabolic syndrome.
在一项针对在职中年男性的横断面研究中，研究了血浆粘度和纤维蛋白原浓度与代谢风险标志物聚集之间的关联。对629名无糖尿病的非吸烟男性（46.7±7.8岁）的子样本进行了分析。还研究了肥胖和心肺适能对这些血液流变学参数的影响及其与代谢综合征的关联。该队列按存在的代谢标志物数量进行分组。代谢标志物包括高密度脂蛋白胆固醇（<1.13 mmol/l）、甘油三酯（≥1.805 mmol/l）、血糖（≥5.5 mmol/l）和舒张压（≥90 mmHg）。与无代谢异常者相比，代谢综合征（三个或更多代谢标志物）患者高粘度（≥1.67 mPa/s）的年龄调整优势比为2.08 [95%置信区间（CI），1.06 - 4.05；P = 0.031]。高纤维蛋白原血症（≥3.47 g/l）的可比年龄调整优势比略高，为1.69，但无统计学意义（95% CI，0.87 - 3.27；P = 0.119）。随着代谢标志物数量的增加，年龄调整后的平均血浆粘度水平和高粘度患病率显著升高，从1.629 mPa/s升至1.692 mPa/s（P = 0.0005），从21.0%升至36.0%（P = 0.006）。在对年龄、血脂和白细胞计数进行调整后，血浆粘度和纤维蛋白原浓度均随皮褶厚度四分位数的升高而增加（分别为P = 0.003和P = 0.01）。血浆粘度也随着预测最大摄氧量（VO2max）水平的升高而显著降低（P = 0.0005）。在对年龄、皮褶厚度总和和预测最大摄氧量（VO2max）进行调整后，代谢综合征患者与无代谢标志物患者相比的高粘度优势比减弱（1.44；95% CI，0.72 - 2.90；P = 0.307）。这些横断面结果表明，血浆粘度与社会经济地位较高的中年男性代谢标志物聚集增加有关。肥胖和心肺适能差可能在与代谢综合征相关的血液流变学异常发展中起重要作用。
