Carroll S, Cooke C B, Butterly R J
School of Leisure and Sports Studies, Leeds Metropolitan University, United Kingdom.
Med Sci Sports Exerc. 2000 Mar;32(3):620-6. doi: 10.1097/00005768-200003000-00011.
The relationship of both leisure time physical activity and predicted maximum oxygen consumption (VO2max) with plasma fibrinogen concentration was examined within a cohort of employed middle-aged men.
Analyses were performed on a subsample of 635 nonsmoking men (46.7 +/- 7.7 yr) who completed a preventive medical assessment between 1992 and 1996.
Among nonsmokers, mean age-adjusted fibrinogen concentration decreased significantly with higher physical activity index (PAL) categories and quartiles of predicted VO2max (mL x kg(-1) x min(-1)) (both P = 0.001). Mean age-adjusted plasma fibrinogen concentrations were significantly different (P < 0.05) between inactive and vigorous PAI groups and extreme quartiles of predicted VO2max (mL x kg(-1) x min(-1)). These relationships were no longer significant after adjustment for the confounding effect of other ischemic heart disease risk factors. Stepwise multiple regression analyses showed that age, sum of skinfolds, and blood leukocyte count were the strongest predictors of plasma fibrinogen concentration.
These data do not confirm a significant independent association of both physical activity and predicted VO2max (mL x kg(-1) x min(-1)) with fibrinogen concentrations among nonsmoking middle-aged men of similar high social class.
在一群在职中年男性中，研究休闲时间身体活动和预测的最大摄氧量（VO2max）与血浆纤维蛋白原浓度之间的关系。
对635名非吸烟男性（46.7±7.7岁）的子样本进行分析，这些男性在1992年至1996年间完成了预防性医学评估。
在非吸烟者中，年龄调整后的平均纤维蛋白原浓度随着身体活动指数（PAL）类别和预测VO2max（毫升×千克⁻¹×分钟⁻¹）四分位数的升高而显著降低（两者P = 0.001）。不活动和剧烈身体活动指数（PAI）组以及预测VO2max（毫升×千克⁻¹×分钟⁻¹）的极端四分位数之间，年龄调整后的平均血浆纤维蛋白原浓度存在显著差异（P < 0.05）。在调整其他缺血性心脏病危险因素的混杂效应后，这些关系不再显著。逐步多元回归分析表明，年龄、皮褶厚度总和和血液白细胞计数是血浆纤维蛋白原浓度的最强预测因素。
这些数据并未证实，在社会阶层相似的非吸烟中年男性中，身体活动和预测的VO2max（毫升×千克⁻¹×分钟⁻¹）与纤维蛋白原浓度之间存在显著的独立关联。
