Tassoni G, Lorenzini C A, Baldi E, Sacchetti B, Bucherelli C
Dipartimento di Scienze Fisiologiche, Università degli Studi di Firenze, Florence, Italy.
Behav Neurosci. 2000 Oct;114(5):875-81.
The role of the perirhinal cortex (PC) in conditioned taste aversion (CTA) learning was investigated in Long Evans rats. CTA was induced by the intraperitoneal administration of LiCl 60 min after saccharin-sweetened water drinking. The PC was reversibly inactivated by the stereotaxic administration of tetrodotoxin (TTX) 60 min before saccharin drinking, immediately after saccharin drinking (Experiment 1), 6 or 24 hr after LiCl administration (Experiment 2), and 60 min before CTA retrieval testing (Experiment 3). Only pre-saccharin drinking PC inactivation disrupted CTA. Thus, PC integrity is necessary only during the earliest phases of CTA mnemonic processing, that is, taste information acquisition and early gustatory memory elaboration. The results are discussed in relation to PC connectivity and PC temporal involvement in the memorization process of other aversive responses.
在长 Evans 大鼠中研究了嗅周皮质（PC）在条件性味觉厌恶（CTA）学习中的作用。在饮用糖精甜水 60 分钟后腹腔注射 LiCl 诱导 CTA。在饮用糖精前 60 分钟、饮用糖精后立即（实验 1）、注射 LiCl 后 6 或 24 小时（实验 2）以及 CTA 检索测试前 60 分钟，通过立体定位注射河豚毒素（TTX）使 PC 可逆性失活。只有饮用糖精前 PC 失活会破坏 CTA。因此，PC 的完整性仅在 CTA 记忆处理的最早阶段是必需的，即味觉信息获取和早期味觉记忆加工阶段。结合 PC 的连接性以及 PC 在其他厌恶反应记忆过程中的时间参与情况对结果进行了讨论。
