Howse Dana J, Squires Amanda S, Martin Gerard M, Skinner Darlene M
Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X9.
Learn Mem. 2003 May-Jun;10(3):161-7. doi: 10.1101/lm.57803.
Rats with perirhinal cortex lesions were compared with sham controls on a conditional discrimination in which saccharin was paired with LiCl in context 1, but paired with saline in context 2. Perirhinal-lesioned rats were slightly slower to acquire the discrimination but reached control levels by the end of acquisition. Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2. Unlike sham rats, perirhinal rats failed to show an aversion to context 1 on a place choice test. These data provide neuroanatomical support for the postulated difference between Pavlovian conditioning and conditional learning.
将患有鼻周皮质损伤的大鼠与假手术对照组进行比较，进行条件性辨别实验。在该实验中，在情境1中糖精与氯化锂配对，但在情境2中与生理盐水配对。患有鼻周皮质损伤的大鼠获得辨别的速度稍慢，但在实验结束时达到了对照组水平。两组都表现出向熟悉的自来水的转移，在情境1中的消耗量比在情境2中少。与假手术大鼠不同，患有鼻周皮质损伤的大鼠在位置选择测试中未表现出对情境1的厌恶。这些数据为巴甫洛夫条件反射和条件学习之间假定的差异提供了神经解剖学支持。
