Masdottir B, Jónsson T, Manfredsdottir V, Víkingsson A, Brekkan A, Valdimarsson H
Department of Immunology and. Radiology, Landspítalinn, University of Iceland, Iceland.
Rheumatology (Oxford). 2000 Nov;39(11):1202-5. doi: 10.1093/rheumatology/39.11.1202.
Smokers have an increased incidence of rheumatoid factor (RF) and rheumatoid arthritis (RA) and one report has also indicated that smoking may also adversely influence the severity of RA.
Sixty-three women with advanced RA answered a structured questionnaire that included detailed information about their smoking history. The women were also evaluated clinically and radiologically.
Heavy smoking (>/= 20 pack-yr) was associated with rheumatoid nodules (P: = 0.01), a higher HAQ score (P: = 0.002) and a lower grip strength (P: = 0.01). Smoking was also associated with more radiological joint damage (P: = 0.02). A positive correlation was observed between smoking and RF levels, in particular IgA RF and a combined elevation of IgM and IgA RF.
Smoking has an adverse effect on disease progression in patients with RA. An association was also observed between smoking and those RF types that predispose to RA and have the highest diagnostic specificity for this disease.
吸烟者类风湿因子（RF）及类风湿关节炎（RA）的发病率增加，且有一份报告指出吸烟可能也会对RA的严重程度产生不利影响。
63名晚期RA女性回答了一份结构化问卷，其中包括有关她们吸烟史的详细信息。这些女性还接受了临床和放射学评估。
重度吸烟（≥20包年）与类风湿结节相关（P = 0.01）、较高的健康评估问卷（HAQ）评分（P = 0.002）及较低的握力（P = 0.01）相关。吸烟还与更多的放射学关节损伤相关（P = 0.02）。观察到吸烟与RF水平呈正相关，尤其是IgA RF以及IgM和IgA RF的联合升高。
吸烟对RA患者的疾病进展有不利影响。还观察到吸烟与那些易患RA且对该病具有最高诊断特异性的RF类型之间存在关联。
