Chang C F, Niu K C, Hoffer B J, Wang Y, Borlongan C V
Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Republic of China.
Exp Neurol. 2000 Dec;166(2):298-306. doi: 10.1006/exnr.2000.7506.
The efficacy of hyperbaric oxygen (HBO) therapy for treatment of stroke remains to be validated in the laboratory. We report here that adult rats subjected to occlusion of the middle cerebral artery and subsequently exposed to HBO (3 atm, 2 x 90 min at a 24-h intervals; animals terminated shortly after the second treatment) or hyperbaric pressure (HBP; 3 atm, 2 x 90 min at a 24-h interval; animals terminated shortly after the second treatment) immediately after the ischemia or after a 60-min delay generally displayed recovery from motor deficits at 2.5 and 24 h of reperfusion, as well as a reduction in cerebral infarction at 24 h of reperfusion compared to ischemic animals subjected to normal atmospheric pressure. While both HBO and HBP treatments promoted beneficial effects, HBO produced more consistent protection than HBP. Treatment with HBO immediately or 60 min after reperfusion equally produced significant attenuations of cerebral infarction and motor deficits. In contrast, protective effects of HBP treatment against ischemia were noted only when administered immediately after ischemia, which resulted in a significantly reduced infarction volume, but only produced a trend toward decreased behavioral deficits. The present results demonstrate that HBO and, to some extent, HBP reduced ischemic brain damage and behavioral dysfunctions.
高压氧（HBO）疗法治疗中风的疗效仍有待在实验室中得到验证。我们在此报告，成年大鼠在大脑中动脉闭塞后，立即或在延迟60分钟后接受HBO（3个大气压，每隔24小时进行2次90分钟治疗；在第二次治疗后不久处死动物）或高压（HBP；3个大气压，每隔24小时进行2次90分钟治疗；在第二次治疗后不久处死动物），与在正常大气压下的缺血动物相比，在再灌注2.5小时和24小时时通常表现出运动功能缺损的恢复，以及在再灌注24小时时脑梗死面积减小。虽然HBO和HBP治疗均产生了有益效果，但HBO比HBP产生的保护作用更一致。在再灌注后立即或60分钟时用HBO治疗同样显著减轻了脑梗死和运动功能缺损。相比之下，仅在缺血后立即给予HBP治疗时才观察到其对缺血的保护作用，这导致梗死体积显著减小，但仅产生行为缺损减少的趋势。目前的结果表明，HBO以及在一定程度上HBP减轻了缺血性脑损伤和行为功能障碍。
