Neurology Clinic, Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
Department of Neurosurgery, Clinical Hospital Center Zemun, Belgrade, Serbia.
Neurol Sci. 2020 Jun;41(6):1381-1390. doi: 10.1007/s10072-020-04241-8. Epub 2020 Jan 11.
Hypoxia is a critical component of neuronal death in patients with stroke. Therefore increasing oxygenation of brain tissue seems to be a logical therapy against cerebral ischemia. Oxygen therapy exists in two modalities: normobaric hyperoxia therapy and hyperbaric oxygen therapy (HBO). HBO is a therapeutic procedure in which pure (100%) oxygen is administered at greater than atmospheric pressure in HBO therapy chambers. In this review article, we aimed to summarize the current knowledge regarding the therapeutic use of HBO in acute stroke patients. Literature review and electronic search were performed using PubMed, Medscape, and UpToDate with the keywords stroke, acute stroke, hyperbaric oxygen therapy, and hyperoxia. According to the reviewed literature, the use of HBO as routine stroke therapy cannot be justified in acute stage of stroke. More randomized, controlled studies are needed regarding safety and especially effectives of HBO in stroke patients. Also, standardized definitionof HBO should be proposed and used in all future studies.
缺氧是中风患者神经元死亡的关键因素。因此，增加脑组织的氧合似乎是对抗脑缺血的合理治疗方法。氧疗有两种方式：常压高氧疗法和高压氧疗法（HBO）。HBO 是一种治疗程序，即在 HBO 治疗室内以高于大气压的压力给予纯（100%）氧气。在这篇综述文章中，我们旨在总结 HBO 在急性中风患者中的治疗应用的现有知识。使用 PubMed、Medscape 和 UpToDate 通过关键词“stroke（中风）”、“acute stroke（急性中风）”、“hyperbaric oxygen therapy（高压氧疗法）”和“hyperoxia（高氧）”进行文献复习和电子搜索。根据已审查的文献，不能将 HBO 作为中风急性期的常规治疗方法。需要更多关于 HBO 在中风患者中的安全性和有效性的随机对照研究。此外，应该在所有未来的研究中提出和使用 HBO 的标准化定义。
