双碟菌素新型类似物的合成及其构效关系
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
作者信息
Takahashi M, Dodo K, Sugimoto Y, Aoyagi Y, Yamada Y, Hashimoto Y, Shirai R
机构信息
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
出版信息
Bioorg Med Chem Lett. 2000 Nov 20;10(22):2571-4. doi: 10.1016/s0960-894x(00)00527-8.
Abstract
The novel analogues of natural cdc25A inhibitor dysidiolide were synthesized. To investigate the structure-activity relationship, the inhibitory activity to enzyme and cell cycle was examined.
摘要
合成了天然cdc25A抑制剂二西地醇内酯的新型类似物。为了研究构效关系，检测了其对酶和细胞周期的抑制活性。
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