Roncero Alejandro M, Tobal Ignacio E, Moro Rosalina F, Diez David, Marcos Isidro S
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Salamanca, Spain.
Front Chem. 2023 Aug 22;11:1225355. doi: 10.3389/fchem.2023.1225355. eCollection 2023.
The development of new anti-cancer agents is an urgent necessity nowadays, as it is one of the major causes of mortality worldwide. Many drugs currently used are derived from natural products. Halimanes are a class of bicyclic diterpenoids present in various plants and microorganisms. Many of them exhibit biological activities such as antitumor, antimicrobial, or anti-inflammatory. Among them, -halimic acid is an easily accessible compound, in large quantities, from the ethyl acetate extract of the plant , and it has been used as a starting material in a number of bioactive molecules. In this work, we review all the natural halimanes with antitumor and related activities until date as well as the synthesis of antitumor compounds using -halimic acid as a starting material.
如今，开发新型抗癌药物迫在眉睫，因为癌症是全球主要的死亡原因之一。目前使用的许多药物都源自天然产物。海松烷是一类存在于各种植物和微生物中的双环二萜。它们中的许多具有抗肿瘤、抗菌或抗炎等生物活性。其中，α-海松酸是一种易于大量从植物的乙酸乙酯提取物中获得的化合物，它已被用作多种生物活性分子的起始原料。在这项工作中，我们综述了迄今为止所有具有抗肿瘤及相关活性的天然海松烷，以及以α-海松酸为起始原料合成抗肿瘤化合物的情况。
