Ciçek S, Attar A, Tuna H, Keçik Y, Egemen N
Department of Anesthesiology, Ankara University Faculty of Medicine, Turkey.
Acta Neurochir (Wien). 2000;142(8):921-7. doi: 10.1007/s007010070079.
The aim of this study is to find out the effects of different doses of midazolam, when used epidurally, on somatosensory evoked potentials (SEP) by delaying neuronal conduction. Thirty two New Zeland albino male rabbits were divided into four groups. All rabbits were anesthetised with ketamine and xylasine combination and atracurium was used as muscle relaxant. 10 mg/kg/hr ketamine infusion was used for maintenance of anesthesia. After insertion of the epidural catheter surgically; Group 1 received 1.5 ml isotonic saline (Control), Group 2 received 150 microg/kg, Group 3 received 250 microg/kg, and Group 4 received 500 microg/kg midazolam epidurally. With the stimulation of sciatic nerve. SEP records were recorded from the epidural space. Records were received before the injection of the drug, and 20, 40, 60 minutes after injection of the drug. "Latency" results were increased according to control in all groups (including isotonic saline-control-group). Increase in latency in the control group was interpreted as due to the effect of temperature mismatch of the saline and the rabbits. While in the first and second group amplitudes showed no differences, group 3 and 4 showed decreases of up to 50%. Epidurally administered midazolam up to 150 microg/kg caused no change in SEP records, but 250 and 500 microg/kg doses caused decreases in SEP records which can lead to misinterpretation as neurological damage.
本研究的目的是探究硬膜外使用不同剂量的咪达唑仑，通过延迟神经元传导对体感诱发电位（SEP）的影响。将32只新西兰白化雄性兔分为四组。所有兔子均用氯胺酮和赛拉嗪联合麻醉，并使用阿曲库铵作为肌肉松弛剂。以10mg/kg/hr的速度输注氯胺酮以维持麻醉。通过手术插入硬膜外导管后；第1组接受1.5ml等渗盐水（对照组），第2组接受150μg/kg，第3组接受250μg/kg，第4组硬膜外接受500μg/kg咪达唑仑。刺激坐骨神经，从硬膜外间隙记录SEP。在注射药物前以及注射药物后20、40、60分钟进行记录。所有组（包括等渗盐水对照组）的“潜伏期”结果均较对照组增加。对照组潜伏期的增加被解释为是由于盐水与兔子体温不匹配的影响。第1组和第2组的波幅无差异，而第3组和第4组波幅下降高达50%。硬膜外给予高达150μg/kg的咪达唑仑对SEP记录无影响，但250μg/kg和500μg/kg剂量会导致SEP记录下降，这可能会被误解为神经损伤。
