2'-羟基查耳酮对大鼠晶状体醛糖还原酶及大鼠血小板聚集的抑制作用。
Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation.
作者信息
Lim S S, Jung S H, Ji J, Shin K H, Keum S R
机构信息
Natural Products Research Institute, Seoul National University, Jongro-gu, Korea.
出版信息
Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1786-9. doi: 10.1248/cpb.48.1786.
Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 microg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.
研究了合成的2'-羟基查耳酮衍生物对大鼠晶状体醛糖还原酶（RLAR）和血小板聚集的抑制作用，以预防或治疗慢性糖尿病并发症。5'-氯-4,2'-二羟基查耳酮（8）和5'-氯-3,2'-二羟基查耳酮（27）对ADP诱导的大鼠血小板聚集（IC50分别为0.10和0.06mg/ml）和胶原诱导的大鼠血小板聚集（IC50分别为44和16μg/ml）表现出强效抑制作用，但对RLAR的抑制活性相对较弱。
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