寻找天然存在的物质以预防糖尿病并发症。II. 香豆素和黄酮类衍生物对牛晶状体醛糖还原酶及兔血小板聚集的抑制作用。
Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation.
作者信息
Okada Y, Miyauchi N, Suzuki K, Kobayashi T, Tsutsui C, Mayuzumi K, Nishibe S, Okuyama T
机构信息
Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1995 Aug;43(8):1385-7. doi: 10.1248/cpb.43.1385.
An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation. Two simple coumarins, scoparone (1) and scopoletin (2), and three flavonoids, capillarisin (21), cirsimaritin (22) and rhamnocitrin (23), were isolated from this extract. Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by four types of agent, ADP, PAF, sodium arachidonate and/or collagen. Capillarisin (21) exhibits a potent inhibitory effect on bovine-LAR. In addition, thirteen simple coumarins, five coumarin glycosides and two flavonoids were tested for their inhibitory effect against bovine-LAR and rabbit platelet aggregation.
茵陈蒿穗的乙酸乙酯提取物可抑制牛晶状体醛糖还原酶（bovine-LAR）和兔血小板聚集。从该提取物中分离出两种简单香豆素，滨蒿内酯（1）和东莨菪内酯（2），以及三种黄酮类化合物，茵陈色原酮（21）、蓟黄素（22）和鼠李柠檬素（23）。滨蒿内酯（1）和东莨菪内酯（2）对由四种试剂，即二磷酸腺苷（ADP）、血小板活化因子（PAF）、花生四烯酸钠和/或胶原蛋白诱导的兔血小板聚集具有强效抑制作用。茵陈色原酮（21）对牛晶状体醛糖还原酶（bovine-LAR）具有强效抑制作用。此外，还测试了13种简单香豆素、5种香豆素苷和2种黄酮类化合物对牛晶状体醛糖还原酶（bovine-LAR）和兔血小板聚集的抑制作用。
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