Guffin A V, Dunbar R W, Kaplan J A, Bland J W
Anesth Analg. 1976 Jan-Feb;55(1):110-3.
The dose of protamine necessary to reverse heparin was examined in 60 patients. Half the patients (controls) received a reversal dose of protamine equal to the entire amount of heparin given them, while half received a reversal dose based on a heparin half-life of 2 hours. Postoperative chest drainage for the first 12 hours and for 48 hours was markedly reduced in patients given the reduced dose of protamine. Platelet counts were higher and postoperative clotting studies varied less from control in patients receiving the smaller dose of protamine. The authors suggest reevaluation of the dose of protamine necessary to reverse the anticoagulant effects of heparin in patients for cardiopulmonary bypass, since larger doses protamine may contribute to the conditions which increase postoperative bleeding.
对60例患者进行了用于逆转肝素作用所需鱼精蛋白剂量的研究。一半患者（对照组）接受的鱼精蛋白逆转剂量等于给予他们的肝素总量，而另一半患者接受的逆转剂量基于肝素2小时的半衰期。给予较低剂量鱼精蛋白的患者术后12小时和48小时的胸腔引流量显著减少。接受较小剂量鱼精蛋白的患者血小板计数较高，术后凝血研究结果与对照组的差异较小。作者建议重新评估在心肺转流患者中逆转肝素抗凝作用所需的鱼精蛋白剂量，因为较大剂量的鱼精蛋白可能会导致增加术后出血的情况。
