Kobayashi Y, Suzuki M, Satsu H, Arai S, Hara Y, Suzuki K, Miyamoto Y, Shimizu M
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Agric Food Chem. 2000 Nov;48(11):5618-23. doi: 10.1021/jf0006832.
Intestinal glucose uptake is mainly performed by the sodium-dependent glucose transporter, SGLT1. The transport activity of SGLT1 was markedly inhibited by green tea polyphenols, this inhibitory activity being most pronounced in polyphenols having galloyl residues such as epicatechin gallate (ECg) and epigallocatechin gallate (EGCg). Experiments using brush-border membrane vesicles obtained from the rabbit small intestine demonstrated that ECg inhibited SGLT1 in a competitive manner, although ECg itself was not transported via SGLT1. The present results suggest that tea polyphenols such as ECg interact with SGLT1 as antagonist-like molecules, possibly playing a role in controlling the dietary glucose uptake in the intestinal tract.
肠道对葡萄糖的摄取主要由钠依赖性葡萄糖转运体SGLT1完成。绿茶多酚可显著抑制SGLT1的转运活性，这种抑制活性在具有没食子酰残基的多酚中最为明显，如儿茶素没食子酸酯（ECg）和表没食子儿茶素没食子酸酯（EGCg）。使用从兔小肠获得的刷状缘膜囊泡进行的实验表明，ECg以竞争性方式抑制SGLT1，尽管ECg本身并不通过SGLT1转运。目前的结果表明，诸如ECg之类的茶多酚作为类似拮抗剂的分子与SGLT1相互作用，可能在控制肠道对膳食葡萄糖的摄取中发挥作用。
