Koeller K M, Wong C H
Department of Chemistry, The Scripps Research Institute and Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Glycobiology. 2000 Nov;10(11):1157-69. doi: 10.1093/glycob/10.11.1157.
The ultimate goal in complex carbohydrate synthesis is to develop synthetic tools which are simple and easily accessible to glycobiologists. This review will describe methods which have the potential to reach this goal, with particular focus on enzymatic and computer-based one-pot approaches for the preparation of complex carbohydrates and glycoconjugates.
复杂碳水化合物合成的最终目标是开发出糖生物学家能够轻松获取且操作简便的合成工具。本综述将描述有可能实现这一目标的方法,特别关注用于制备复杂碳水化合物和糖缀合物的酶促和基于计算机的一锅法。