抗菌药物在人类治疗和农业中的应用以及人类肠道菌群的耐药性。
Human therapeutic and agricultural uses of antibacterial drugs and resistance of the enteric flora of humans.
作者信息
Siegel D, Huber W G, Drysdale S
出版信息
Antimicrob Agents Chemother. 1975 Nov;8(5):538-43. doi: 10.1128/AAC.8.5.538.
Fecal samples were collected from five groups of people differing in the manner of their exposure to antibacterial drugs. The groups included: (i) people working on farms who were continuously in contact with the predominantly resistant florae of farm animals receiving rations containing antibacterial drugs, (ii) people residing on the same farms with no direct exposure to the farm animals, (iii) people treated with antibacterial drugs, (iv) untreated people residing with treated individuals, and (v) untreated people with no exposure to farm animals or treated individuals. The samples were examined by quantitative plating for proportions of antibiotic-resistant, gram-negative enteric organisms. Individual isolates were also examined for their susceptibility to 11 different antibacterial drugs. The results indicate that enteric florae unexposed directly to the selective effects of antibacterial drugs may be affected by contact with predominantly resistant florae directly exposed to antibacterial drugs.
从五组接触抗菌药物方式不同的人群中采集粪便样本。这些组包括：（i）在农场工作且持续接触食用含抗菌药物饲料的农场动物中主要的耐药菌群的人员；（ii）居住在同一农场但未直接接触农场动物的人员；（iii）接受抗菌药物治疗的人员；（iv）与接受治疗的个体同住的未治疗人员；以及（v）未接触农场动物或接受治疗个体的未治疗人员。通过定量培养法检测样本中耐抗生素革兰氏阴性肠道菌的比例。还检测了各个分离菌株对11种不同抗菌药物的敏感性。结果表明，未直接接触抗菌药物选择作用的肠道菌群可能会受到与直接接触抗菌药物的主要耐药菌群接触的影响。
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