Ojeniyi A A
Gastro-enterology Department of Medicine, Rigshospitalet-National University Hospital, Copenhagen, Denmark.
Epidemiol Infect. 1989 Dec;103(3):513-22. doi: 10.1017/s0950268800030910.
Eight hundred and sixty-four Escherichia coli isolates from workers at the University of Ibadan Teaching and Research Poultry Farm, and 216 isolates from poultry attendants at a commercial poultry farm in the city were found to be resistant to streptomycin, sulphafurazole and tetracycline. In contrast, all 576 and 288 E. coli isolates from village fowls and from villagers respectively were sensitive to these drugs. Isolates from birds in a modern university poultry unit (3744) exhibited the same resistance patterns as those isolated from workers who were in direct contact with the birds. No nalidixic acid-resistant E. coli was isolated from farm workers prior to their assignment to the experimental pen. Following experimental oral infection of birds with E. coli K12 J5 NA+ Lac-, the organism was recovered from the workers who manned the experimental pen. Neither before nor after the experimental infection was any nalidixic acid-resistant E. coli isolated from workers who manned the pen from which birds used in the experiment were selected. Similarly, no drug resistant organisms were isolated from workers outside the poultry unit of the university or commercial farm. The MIC of the drugs against the avian and human E. coli isolates at the university and commercial poultry farms were similar.
从伊巴丹大学教学与研究家禽场的工作人员中分离出的864株大肠杆菌，以及从该市一家商业家禽场的家禽饲养员中分离出的216株大肠杆菌，被发现对链霉素、磺胺异恶唑和四环素具有抗性。相比之下，分别从乡村家禽和村民中分离出的所有576株和288株大肠杆菌对这些药物敏感。来自一所现代大学家禽养殖场（3744株）禽类的分离株与从与禽类有直接接触的工作人员中分离出的菌株表现出相同的抗性模式。在将农场工人分配到实验围栏之前，未从他们身上分离出耐萘啶酸的大肠杆菌。在用大肠杆菌K12 J5 NA+ Lac-对禽类进行实验性口服感染后，从负责实验围栏的工作人员身上分离出了该微生物。在实验感染之前和之后，从选出用于实验的禽类所在围栏的负责工作人员身上均未分离出耐萘啶酸的大肠杆菌。同样，在大学或商业养殖场的家禽养殖单元之外的工作人员中也未分离出耐药菌。这些药物对大学和商业家禽养殖场的禽类及人类大肠杆菌分离株的最低抑菌浓度相似。
