Celniker S E
Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Curr Opin Genet Dev. 2000 Dec;10(6):612-6. doi: 10.1016/s0959-437x(00)00140-4.
The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced-yeast, worm and fly-including an analysis of the fly's influences as a model for the study of human disease. This year has also seen the initiation of a full-length cDNA sequencing project and the first analysis of Drosophila development using high-density DNA microarrays containing several thousand Drosophila genes. For the first time homologous recombination has been demonstrated in flies and targeted gene disruptions may not be far off.
过去一年对果蝇研究来说是引人注目的一年。黑腹果蝇基因组的测序和注释使得对最早测序的三种真核生物——酵母、线虫和果蝇——进行全面分析成为可能，其中包括分析果蝇作为人类疾病研究模型所产生的影响。今年还启动了一个全长cDNA测序项目，并首次使用包含数千个果蝇基因的高密度DNA微阵列对果蝇发育进行分析。果蝇中首次证明了同源重组，靶向基因破坏可能也为期不远了。
