Cogoni C, Macino G
Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma La Sapienza, Viale Regina Elena, 324, 00161 Roma, Italy.
Curr Opin Genet Dev. 2000 Dec;10(6):638-43. doi: 10.1016/s0959-437x(00)00134-9.
Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena. The ubiquitous presence of PTGS in both the plant and animal kingdoms and the finding of common genetic mechanisms suggest that PTGS is a universal gene-regulation system fundamental in biological processes such as protection against viruses and transposons.
由于导入转基因或双链RNA分子而导致的转录后基因沉默（PTGS）已在许多物种中被发现。在过去的一年里，不同系统的研究极大地增进了我们对这些现象分子机制的理解。PTGS在植物和动物界普遍存在，以及共同遗传机制的发现表明，PTGS是一种普遍的基因调控系统，在诸如抵御病毒和转座子等生物过程中至关重要。
