Mazzaferri E L, Reynolds J C, Young R L, Thomas C N, Parisi A F
Arch Intern Med. 1976 Jan;136(1):50-6.
It has been suggested that propranolol hydrochloride alone is effective in the treatment of thyrotoxicosis. To test this hypothesis, eight mildly thyrotoxic individuals were prospectively studied for an average of eight months, during which propranolol alone was administered and thyroid function tests, cardiac systolic time intervals, and body densities were sequentially measured. Two patients became euthyroid. The others had adequate but incomplete symptomatic control. Weight loss was not corrected, but no changes in lean body mass were induced. The augmented myocardial contractility of thyrotoxicosis, as determined by systolic time intervals, improved but failed to return completely to normal. Thus, systolic time intervals are a practical means of following the peripheral response to chronic beta-adrenergic blockage in thyrotoxic patients. However, these observations do not support the use of propranolol alone as the first choice of therapy for thyrotoxicosis.
有人提出，单独使用盐酸普萘洛尔对治疗甲状腺毒症有效。为验证这一假设，对8名轻度甲状腺毒症患者进行了前瞻性研究，平均为期8个月，在此期间仅给予普萘洛尔，并依次测量甲状腺功能测试、心脏收缩时间间期和身体密度。两名患者甲状腺功能恢复正常。其他患者有充分但不完全的症状控制。体重减轻未得到纠正，但瘦体重没有变化。通过收缩时间间期确定的甲状腺毒症患者增强的心肌收缩力有所改善，但未能完全恢复正常。因此，收缩时间间期是跟踪甲状腺毒症患者对慢性β-肾上腺素能阻滞外周反应的实用方法。然而，这些观察结果不支持单独使用普萘洛尔作为甲状腺毒症治疗的首选疗法。
